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Belzutifan is usually a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors might maximize incidence or severity of adverse consequences. Monitor for anemia and hypoxia and reduce belzutifan dose as advisable.saquinavir will enhance the stage or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/W